Go to page
 

Bibliographic Metadata

Title
Uptake and metabolism of the antidepressants sertraline, clomipramine, and trazodone in a garden cress (Lepidium sativum) model
AuthorReichl, Bernd ; Himmelsbach, Markus ; Emhofer, Lisa ; Klampfl, Christian W. ; Buchberger, Wolfgang
Published in
Electrophoresis, 2018, Vol. 39, Issue 9-10, page 1301-1308
PublishedWiley, 2018
LanguageEnglish
Document typeJournal Article
Keywords (EN)Environmental analysis / High performance liquid chromatographymass spectrometry / Plants / Xenobiotics
Project-/ReportnumberI3046
ISSN1522-2683
URNurn:nbn:at:at-ubl:3-1616 Persistent Identifier (URN)
DOI10.1002/elps.201700482 
Restriction-Information
 The work is publicly available
Files
Uptake and metabolism of the antidepressants sertraline, clomipramine, and trazodone in a garden cress (Lepidium sativum) model [0.53 mb]
Links
Reference
Classification
Abstract (English)

Environmental contamination with pharmaceuticals has received growing attention in recent years. Several studies describe the presence of traces of drugs in water bodies and soils and their impacts on nontarget organisms including plants. Due to these facts investigations of the uptake and metabolism of pharmaceuticals in organisms is an emerging research area. The present study demonstrates the analysis of three selected antidepressants (sertraline, clomipramine, and trazodone) as well as metabolites and transformation products in a cress model (Lepidium sativum). Cress was treated with tap water containing 10 mg/L of the parent drugs. Employing an analytical approach based on high performance liquid chromatography coupled with quadrupole time of flight or Orbitrap mass spectrometry in MS and MS modes, in total 14 substances were identified in the cress extracts. All three parent drugs were taken up by the cress and translocated from the roots to the leaves in specific patterns. In addition to this, eleven metabolite species were identified. They were generated by hydroxylation, demethylation, conjugation with amino acids, or combinations of these mechanisms. Finally, the inclusion of control cultures in the experimental setup allowed for a differentiation of “true” metabolites generated by the cress and transformation products generated by plantindependent mechanisms.

Stats
The PDF-Document has been downloaded 2 times.
License
CC-BY-License (4.0)Creative Commons Attribution 4.0 International License